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© Kirrawee Veterinary Hospital FELINE DISEASES
Inflamatroy Bowel Disease
This syndrome is probably the most common cause of chronic diarrhoea
and vomiting in dogs and cats. The underlying cause of this disease
is not clearly defined and is probably a combination of infection
with either bacteria or protozoa and inflammation or allergy.
Clinical signs typically involve increased frequency of defecation
with reduced volume. Often mucus and sometimes blood is seen in
the faeces. Straining is another common feature. most animals
remain in reasonable body condition and show no other signs of
illness. A range of bacteria have been isolated from these animals however
none have been found on a consistent basis. The classical finding
is inflammation of the lining of the gut with infiltration by
a range of inflammatory cell types which suggests a broad allergic
reaction to either food or bacteria. Protozoa (small parasites which invade gut cells) infection damages
the lining of the intestine and reduces the absorption of fluids.
One of the most common protozoa of animals and humans is Giardia.
Infection is via eating contaminated material. Most infected animals
show no symptoms however some animals especially the young can
develop intermittent diarrhoea and straining possibly with blood. DIagnosis of Inflammatory Bowel Disease can be very difficult
as faecal tests and blood tests are usually unremarkable. Even
Giardia only appear in around 20% of faecal samples from effected
animals. Occasionally liver enzymes are increased due to absorption
of liver toxins through the damaged gut. The best diagnostic procedure
biopsy where a sample of the intestinal lining is taken for microscopic
examination. A range of treatments have been used for IBD however dietary management
remains the primary therapy. Where the signs of IBD are more acute
the animal is fasted (no food) for 2-3 days. This is followed
by a low allergy (hypoallergenic) diet which uses a single protein
and carbohydrate such as chicken as rice. The diet is maintained
for 10 days before any changes are considered. If the diet has
been successful other components can be gradually introduced.
Where there is no improvement the protein and/or carbohydrate
should be changed. Other treatment regimes include antibacterial / antiiflamatory
drugs which include:
Sulfasalazine
- combination of Sulpha drugs (antibacterial) and salicylate
(aspirin family). Metronidiazole - antibacterial, anitprotozoal,
and suppresses immune reactions.
Tylosin - antibiotic found to effective in some cases
mechanism unknown.
Corticosteroids - these are generally on
partial effective in controlling IBD and are mostly used in combination
with other drugs.
Chemotherapy has also been used in protracted
cases with some success, Azathioprine being the most commonly
used drug.
Fenbendazole at 50mg/kg/day for 3 days has
been shown to effective against Giardia. Related sites |